ORIGINAL ARTICLEMolecular engineering of antibodies for site-specific conjugation to lipid polydopamine hybrid nanoparticles
Under a Creative Commons license
open access
Graphical abstract
An anti-claudin 3 antibody was engineered to contain a single cysteine residue, and linked to the maleimide group of lipid polydopamine hybrid nanoparticles. Anti-claudin 3 antibody-modified nanoparticles were specifically recognized by claudin 3-overexpressing cells. Systemic administration of anti-claudin 3 antibody-modified nanoparticles provided tumor ablation upon near infrared irradiation.
Key words
Molecular engineering
Site-specific conjugation
Lipid polydopamine hybrid nanoparticles
Claudin 3
Photothermal therapy
Cited by (0)
Peer review under the responsibility of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.
- †
These authors made equal contributions to this work.
© 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.